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Polyphenols: nutraceutical approach towards chronic fatigue Polyphenols are one of the most potent antioxidant phytochemicals, whose antioxidant effects are attributed to their ability to increase antioxidant defenses

ChenXPanZFangZLinWWuSYangFet al

Environ Int 74:4253

Another study evaluated the antioxidant action of ALA in trained men exposed to muscle-damaging exercises [118]

Further, CII enhances the expression of the MSU-induced chemokines CXC motif chemokine ligand 2 (CXCL2), Chemokine (C-C motif) ligand 2 (CCL2), and the pro-inflammatory cytokine IL-1 in macrophages